Four-Coordinate, Low-Spin (S = 0) and Six-Coordinate, High-Spin (S = 1) Nickel(II) Complexes of Tetraphenylporphyrins with β-Pyrrole Electron-Withdrawing Substituents: Porphyrin-Core Expansion and Conformation. Hugues Duval, Véronique Bulach, Jean Fischer, and, Raymond Weiss.Journal of the American Chemical Society 2000, 122 A First-Principles Quantum Chemical Study of Coenzyme F430: Interplay of Skeletal Stereoisomerism and Conformation in the Stabilization of Nickel(I). Mixed Substituted Porphyrins: Structural and Electrochemical Redox Properties. The Journal of Physical Chemistry B 2008, 112 A New Mechanism for Methane Production from Methyl-Coenzyme M Reductase As Derived from Density Functional Calculations. Geometric and Electronic Structures of the NiI and Methyl−NiIII Intermediates of Methyl-Coenzyme M Reductase. Ritimukta Sarangi, Mishtu Dey and Stephen W.Influence of Mixed Substituents on the Macrocyclic Ring Distortions of Free Base Porphyrins and Their Metal Complexes. Porphyrin−Fullerene, C60, Cocrystallates: Influence of C60 on the Porphyrin Ring Conformation. Saddle Distortion of a Sterically Unhindered Porphyrin Ring in a Copper Porphyrin with Electron-Donating Substituents. Synthesis, Spectral, and Electrochemical Studies of Electronically Tunable β-Substituted Porphyrins with Mixed Substituent Pattern. Asymmetrically Crowded “Push–Pull” Octaphenylporphyrins with Modulated Frontier Orbitals: Syntheses, Photophysical, and Electrochemical Redox Properties. Nitika Grover, Muniappan Sankar, Yang Song, and Karl M.More information can be found here.This article is cited by 57 publications. This novel mechanism of action is designed to support safer and more predictable bone formation compared to commercially available bone growth factors. i-FACTOR Peptide Enhanced Bone Graft is the only biologic bone graft in orthopedics that incorporates a small peptide as an attachment factor to stimulate the natural bone healing process. i-FACTOR Peptide Enhanced Bone Graft must be used inside an allograft bone ring and with supplemental anterior plate fixation.Ĭerapedics is an ortho-biologics company focused on developing and commercializing its proprietary small peptide (P-15) technology platform. In the United States, i-FACTOR Peptide Enhanced Bone Graft is indicated for use in skeletally mature patients for reconstruction of a degenerated cervical disc at one level from C3-C4 to C6-C7 following single-level discectomy for intractable radiculopathy (arm pain and/or a neurological deficit), with or without neck pain, or myelopathy due to a single-level abnormality localized to the disc space, and corresponding to at least one of the following conditions confirmed by radiographic imaging (CT, MRI, X-rays): herniated nucleus pulposus, spondylosis (defined by the presence of osteophytes), and/or visible loss of disc height as compared to adjacent levels, after failure of at least 6 weeks of conservative treatment. i-FACTOR+ Matrix is the same technology as the P15-L investigational material in the IDE," said Jeffrey Marx, Ph.D., President and Chief Operating Officer of Cerapedics.ĬAUTION: In the United States, P-15L Bone Graft (i-FACTOR+ Matrix) is an Investigational Product limited by Federal Law to investigational use only. "In addition to the commercial launch in Canada, the latest i-FACTOR+ MATRIX generation is currently being studied in our FDA IDE study, ASPIRE, targeting lumbar fusions (TLIF), as previously announced. Food and Drug Administration (FDA) premarket approval (PMA) application in 2015 only for use in single-level anterior cervical fusion procedures. In the United States, i-FACTOR Peptide Enhanced Bone Graft was approved via a U.S. Cerapedics initial P-15 technology product, i-FACTOR Peptide Enhanced Bone Graft, was approved in the European Union in 2008 and Australia in 2010 for use in the repair of bony voids or defects in orthopedic applications throughout the skeletal system (i.e., the spine and extremities). I-FACTOR+ MATRIX utilizes a small proprietary peptide (P-15) technology developed by Cerapedics to support bone growth through cell attraction, attachment, and activation. " Canada will be the first market offering the i-FACTOR+ MATRIX product, which leverages the clinically proven P-15 osteogenic cell-binding peptide combined with a collagen carrier for optimized handling." "We are excited to announce that i-FACTOR+ Matrix is now fully available in Canada through our distributor Surgi-One and can be used in both spine and general orthopedic applications," said Glen Kashuba, Chief Executive Officer of Cerapedics. 5, 2020 /CNW/ - Cerapedics, a private ortho-biologics company, today announced the full commercial availability of i-FACTOR+ MATRIX for surgical implantation in Canada. Canada will be the first commercial market to launch i-FACTOR ®+ Matrix
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